Ignacio Lizarraga-Madrigal

Doctor of Philosophy, (Veterinary Science)
Study Completed: 2006
College of Sciences

Citation

Thesis Title
Spinal analgesic interaction between non-steroidal anti-inflammatory drugs and N-methyl D-aspartate receptor systems.

Read article at Massey Research Online: MRO icon

Dr Lizarraga-Madrigal studied the potential analgesic interactions between aspirin-like drugs and NMDA receptor systems at the spinal cord level. He carried out a series of studies. The studies’ objectives involved identifying drug combinations that would control pain in a more efficient way and produce less side effects compared to individual drugs. Using electrophysiological and behavioural techniques, his research showed that combinations of ketoprofen, ketamine and L-NAME may be useful for controlling pain and producing less side effects compared to using each individual drug. These findings may be of clinical relevance for both animals and humans

Supervisors
Professor Craig Johnson

Catch
additional
Struct (ordered)
Detail
string
ErrorCode
string0
Extended_Info
string
ExtendedInfo
string
Message
stringCan't create file [/var/www/massey/_mucache/wagtail/footer.cfm]
StackTrace
stringlucee.runtime.exp.NativeException: Can't create file [/var/www/massey/_mucache/wagtail/footer.cfm] at lucee.commons.io.res.type.file.FileResource.getOutputStream(FileResource.java:262) at lucee.runtime.functions.file.FileStreamWrapperWrite._getOS(FileStreamWrapperWrite.java:138) at lucee.runtime.functions.file.FileStreamWrapperWrite.write(FileStreamWrapperWrite.java:69) at lucee.runtime.functions.file.FileWrite.call(FileWrite.java:51) at massey.app_templates._pagetemplates._templatefiles.tmp_ot_wagtail.footer_auto_cfm$cf.call(/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/footer_auto.cfm:49) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:1056) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:948) at lucee.runtime.PageContextImpl.doInclude(PageContextImpl.java:929) at massey.app_templates._pagetemplates._templatefiles.tmp_ot_wagtail.base_cfm$cf.call(/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/base.cfm:106) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:1056) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:948) at lucee.runtime.PageContextImpl.doInclude(PageContextImpl.java:929) at massey.app_templates._pagetemplates.tmp_ot_wagtail_cfm$cf.call(/massey/app_templates/_pagetemplates/tmp_OT_wagtail.cfm:10) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:1056) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:948) at lucee.runtime.PageContextImpl.doInclude(PageContextImpl.java:929) at massey.app_templates.index_cfm$cf.call(/massey/app_templates/index.cfm:329) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:1056) at lucee.runtime.PageContextImpl._doInclude(PageContextImpl.java:948) at lucee.runtime.listener.ModernAppListener._onRequest(ModernAppListener.java:219) at lucee.runtime.listener.MixedAppListener.onRequest(MixedAppListener.java:44) at lucee.runtime.PageContextImpl.execute(PageContextImpl.java:2493) at lucee.runtime.PageContextImpl._execute(PageContextImpl.java:2478) at lucee.runtime.PageContextImpl.executeCFML(PageContextImpl.java:2449) at lucee.runtime.engine.Request.exe(Request.java:45) at lucee.runtime.engine.CFMLEngineImpl._service(CFMLEngineImpl.java:1216) at lucee.runtime.engine.CFMLEngineImpl.serviceCFML(CFMLEngineImpl.java:1162) at lucee.loader.engine.CFMLEngineWrapper.serviceCFML(CFMLEngineWrapper.java:97) at lucee.loader.servlet.CFMLServlet.service(CFMLServlet.java:51) at javax.servlet.http.HttpServlet.service(HttpServlet.java:623) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:199) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:144) at org.apache.tomcat.websocket.server.WsFilter.doFilter(WsFilter.java:51) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:168) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:144) at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:168) at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:90) at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:482) at org.apache.catalina.valves.rewrite.RewriteValve.invoke(RewriteValve.java:287) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:130) at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:93) at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:660) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:74) at org.apache.catalina.valves.rewrite.RewriteValve.invoke(RewriteValve.java:532) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:130) at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:93) at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:660) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:74) at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:346) at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:396) at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:63) at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:937) at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1793) at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:52) at org.apache.tomcat.util.threads.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1190) at org.apache.tomcat.util.threads.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:659) at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:63) at java.base/java.lang.Thread.run(Thread.java:829) Caused by: java.io.IOException: Can't create file [/var/www/massey/_mucache/wagtail/footer.cfm] ... 58 more
TagContext
Array
1
Struct
codePrintHTML
string47: request.wagtail_footer = &quot;&lt;&quot; &amp; 'cfprocessingdirective pageEncoding=&quot;utf-8&quot;' &amp; &quot;&gt;#chr(10)#&quot;;<br> 48: request.wagtail_footer &amp;= reMatchNoCase(&quot;&lt;footer[^&gt;]*?&gt;.+?&lt;/footer&gt;&quot;, response.filecontent)[1];<br> <b>49: fileWrite(filePath=request.cacheWagtailFooterFile, data=request.wagtail_footer, charset=&quot;utf-8&quot;);</b><br> 50: server.wagtail_footer_cache_time = now();<br> 51: <br>
codePrintPlain
string47: request.wagtail_footer = "<" & 'cfprocessingdirective pageEncoding="utf-8"' & ">#chr(10)#"; 48: request.wagtail_footer &= reMatchNoCase("<footer[^>]*?>.+?</footer>", response.filecontent)[1]; 49: fileWrite(filePath=request.cacheWagtailFooterFile, data=request.wagtail_footer, charset="utf-8"); 50: server.wagtail_footer_cache_time = now(); 51:
column
number0
id
string??
line
number49
Raw_Trace
stringmassey.app_templates._pagetemplates._templatefiles.tmp_ot_wagtail.footer_auto_cfm$cf.call(/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/footer_auto.cfm:49)
template
string/var/www/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/footer_auto.cfm
type
stringcfml
2
Struct
codePrintHTML
string104: &lt;/main&gt;<br> 105: <br> <b>106: &lt;cfinclude template=&quot;./footer_auto.cfm&quot;&gt;</b><br> 107: <br> 108: &lt;/div&gt;<br>
codePrintPlain
string104: </main> 105: 106: <cfinclude template="./footer_auto.cfm"> 107: 108: </div>
column
number0
id
string??
line
number106
Raw_Trace
stringmassey.app_templates._pagetemplates._templatefiles.tmp_ot_wagtail.base_cfm$cf.call(/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/base.cfm:106)
template
string/var/www/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/base.cfm
type
stringcfml
3
Struct
codePrintHTML
string8: &lt;cfset directoryCreate(ExpandPath(&quot;/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/_js/cache/&quot;))&gt;<br> 9: &lt;/cfif&gt;<br> <b>10: &lt;cfinclude template=&quot;_templatefiles/#request.template_name#/base.cfm&quot; &gt;</b><br>
codePrintPlain
string8: <cfset directoryCreate(ExpandPath("/massey/app_templates/_pagetemplates/_templatefiles/tmp_OT_wagtail/_js/cache/"))> 9: </cfif> 10: <cfinclude template="_templatefiles/#request.template_name#/base.cfm" >
column
number0
id
string??
line
number10
Raw_Trace
stringmassey.app_templates._pagetemplates.tmp_ot_wagtail_cfm$cf.call(/massey/app_templates/_pagetemplates/tmp_OT_wagtail.cfm:10)
template
string/var/www/massey/app_templates/_pagetemplates/tmp_OT_wagtail.cfm
type
stringcfml
4
Struct
codePrintHTML
string327: &lt;/cfsavecontent&gt;<br> 328: &lt;/cfif&gt;<br> <b>329: &lt;cfinclude template=&quot;#request.sapi.site.getTemplate()#&quot;&gt;</b><br> 330: &lt;cfelse&gt;<br> 331: &lt;!--- presume if page_title doesn't exist that they are trying to view a page that does not exist in another language' ---&gt;<br>
codePrintPlain
string327: </cfsavecontent> 328: </cfif> 329: <cfinclude template="#request.sapi.site.getTemplate()#"> 330: <cfelse> 331: <!--- presume if page_title doesn't exist that they are trying to view a page that does not exist in another language' --->
column
number0
id
string??
line
number329
Raw_Trace
stringmassey.app_templates.index_cfm$cf.call(/massey/app_templates/index.cfm:329)
template
string/var/www/massey/app_templates/index.cfm
type
stringcfml
type
stringjava.io.IOException